The Jarid1C Polyclonal Antibody from Bioss Inc. is a Rabbit Polyclonal antibody to MAP4K1. This antibody recognizes Human antigen. The Jarid1C Polyclonal Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.Tissue specificity:br>Involvement in disease:Defects in KDM5C are the cause of mental retardation syndromic X-linked JARID1C-related (MRXSJ). MRXSJ is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRXSJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism